What causes high Bilirubin direct and low Globulin?

High Bilirubin direct and low Globulin can be caused by many reasons.

If your Bilirubin direct is in between 0.1 mg/dL and 0.2 mg/dL and your Globulin is in between 2 g/dL and 4.1 g/dL then you need not worry as these are the normal ranges for Bilirubin direct and Globulin respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease Bilirubin levels include:

• Gallstones present in the bile ducts
• Hepatitis A, hepatitis B, hepatitis C
• Scarring of the bile ducts
• Lack of oxygen (hypoxia)
• Liver disease

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Normal range of Bilirubin direct : 0.1 - 0.2 mg/dL

Ideal values of Bilirubin direct depending on age :

Age	Ideal Bilirubin direct value
<5 years	0.11924
5-10 years	0.12926
10-15 years	0.14012
15-20 years	0.15189
20-25 years	0.16465
25-30 years	0.17848
30-35 years	0.19347
35-40 years	0.1921
40-45 years	0.19075
45-50 years	0.1894
50-55 years	0.18806
55-60 years	0.18674
60-70 years	0.18543
70-80 years	0.18413
80-90 years	0.1996
90-100 years	0.19819
>100 years	0.19679

*Ideal values are calculated based on our database of patient records

Normal range of Globulin : 2 - 4.1 g/dL

Ideal values of Globulin depending on age :

Age	Ideal Globulin value
<5 years	2.168
5-10 years	2.35
10-15 years	2.547
15-20 years	2.761
20-25 years	2.993
25-30 years	3.244
30-35 years	3.516
35-40 years	3.811
40-45 years	3.784
45-50 years	3.757
50-55 years	4.073
55-60 years	4.044
60-70 years	4.016
70-80 years	3.987
80-90 years	3.959
90-100 years	3.931
>100 years	3.903

High Bilirubin direct and low Globulin can be caused by a lot of reasons. If you take Bilirubin direct and Globulin blood tests and the results are higher than 0.2 mg/dL for Bilirubin direct and lower than 2 g/dL for Globulin, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the Bilirubin direct and Globulin Tests Are Done :

If your doctor wants Bilirubin direct and Globulin tests on you, you may need to go through these tests. During the Bilirubin direct and Globulin blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Bilirubin direct and Globulin Test reports by your pathologist.

Medical References

• Cleveland Clinic – Bilirubin Test: Understanding High vs. Low Levels & Causes
• Mayo Clinic – Bilirubin test
• MedlinePlus – Bilirubin Blood Test
• Medscape – Bilirubin: Reference Range, Interpretation, Collection and Panels
• NCBI – Evaluating Elevated Bilirubin Levels in Asymptomatic Adults