What causes high INR and low Bilirubin direct?

High INR and low Bilirubin direct can be caused by many reasons.

If your INR is in between 0.9 ratio and 1.2 ratio and your Bilirubin direct is in between 0.1 mg/dL and 0.2 mg/dL then you need not worry as these are the normal ranges for INR and Bilirubin direct respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease INR levels include:

• Liver disease
• Vitamin K abnormality
• Decreased or defective factor I (fibrinogen), II (prothrombin), V or X
• Hemophilia A and hemophilia B
• Autoantibody against a specific factor (e.g., factor VIII)

Normal range of INR : 0.9 - 1.2 ratio

Ideal values of INR depending on age :

Age	Ideal INR value
<5 years	0.947
5-10 years	0.996
10-15 years	1.048
15-20 years	1.102
20-25 years	1.159
25-30 years	1.156
30-35 years	1.153
35-40 years	1.15
40-45 years	1.147
45-50 years	1.144
50-55 years	1.14
55-60 years	1.199
60-70 years	1.195
70-80 years	1.192
80-90 years	1.189
90-100 years	1.186
>100 years	1.183

*Ideal values are calculated based on our database of patient records

Normal range of Bilirubin direct : 0.1 - 0.2 mg/dL

Ideal values of Bilirubin direct depending on age :

Age	Ideal Bilirubin direct value
<5 years	0.11572
5-10 years	0.12174
10-15 years	0.12807
15-20 years	0.13473
20-25 years	0.14174
25-30 years	0.14911
30-35 years	0.15686
35-40 years	0.16502
40-45 years	0.1736
45-50 years	0.18263
50-55 years	0.19213
55-60 years	0.19161
60-70 years	0.19109
70-80 years	0.19058
80-90 years	0.19006
90-100 years	0.19994
>100 years	0.1994

High INR and low Bilirubin direct can be caused by a lot of reasons. If you take INR and Bilirubin direct blood tests and the results are higher than 1.2 ratio for INR and lower than 0.1 mg/dL for Bilirubin direct, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the INR and Bilirubin direct Tests Are Done :

If your doctor wants INR and Bilirubin direct tests on you, you may need to go through these tests. During the INR and Bilirubin direct blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your INR and Bilirubin direct Test reports by your pathologist.

Medical References

• MedlinePlus – Prothrombin Time Test and INR (PT/INR)
• Mayo Clinic – Prothrombin time test
• Cleveland Clinic – Prothrombin Time (PT/INR) Test