What causes high MPV and low Vitamin B12?

High MPV and low Vitamin B12 can be caused by many reasons.

If your MPV is in between 6.8 fL and 10.9 fL and your Vitamin B12 is in between 211 pg/mL and 911 pg/mL then you need not worry as these are the normal ranges for MPV and Vitamin B12 respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease MPV levels include:

• Primary or secondary thrombocytosis
• Marrow hypoplasia.
• Heart disease
• Autoimmune diseases
• Atrial fibrillation, irregular heartbeat

Normal range of Vitamin B12 : 211 - 911 pg/mL

Ideal values of Vitamin B12 depending on age :

Age	Ideal Vitamin B12 value
<5 years	216.359
5-10 years	221.855
10-15 years	227.49
15-20 years	233.268
20-25 years	239.193
25-30 years	245.269
30-35 years	251.499
35-40 years	257.887
40-45 years	264.437
45-50 years	271.154
50-55 years	278.041
55-60 years	285.103
60-70 years	292.345
70-80 years	299.771
80-90 years	307.385
90-100 years	315.193
>100 years	323.199

High MPV and low Vitamin B12 can be caused by a lot of reasons. If you take MPV and Vitamin B12 blood tests and the results are higher than 10.9 fL for MPV and lower than 211 pg/mL for Vitamin B12, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the MPV and Vitamin B12 Tests Are Done :

If your doctor wants MPV and Vitamin B12 tests on you, you may need to go through these tests. During the MPV and Vitamin B12 blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your MPV and Vitamin B12 Test reports by your pathologist.

Medical References

• Cleveland Clinic – MPV Blood Test
• MedlinePlus – MPV Blood Test
• Verywell Health – MPV Blood Test: What Low and High Test Results Mean
• PubMed – What a Family Doctor Should Know about Incidental Finding of High Mean Platelet Volume
• Health.com – Understanding Your Mean Platelet Volume (MPV) Blood Test