What causes high Prothrombin time and low TIBC?

High Prothrombin time and low TIBC can be caused by many reasons.

If your Prothrombin time is in between 12 seconds and 16 seconds and your TIBC is in between 250 mcg/dL and 450 mcg/dL then you need not worry as these are the normal ranges for Prothrombin time and TIBC respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease Prothrombin time levels include:

• Liver disease
• Vitamin K abnormality
• Hemophilia A and hemophilia B
• Decreased or defective factor I (fibrinogen), II (prothrombin), V or X
• Willebrand disease

Normal range of Prothrombin time : 12 - 16 seconds

Ideal values of Prothrombin time depending on age :

Age	Ideal Prothrombin time value
<5 years	12.129
5-10 years	12.259
10-15 years	12.39
15-20 years	12.523
20-25 years	12.657
25-30 years	12.793
30-35 years	12.93
35-40 years	13.068
40-45 years	13.208
45-50 years	13.349
50-55 years	13.492
55-60 years	13.636
60-70 years	13.782
70-80 years	13.93
80-90 years	14.079
90-100 years	14.23
>100 years	14.382

*Ideal values are calculated based on our database of patient records

Normal range of TIBC : 250 - 450 mcg/dL

Ideal values of TIBC depending on age :

Age	Ideal TIBC value
<5 years	252.678
5-10 years	255.384
10-15 years	258.119
15-20 years	260.883
20-25 years	263.677
25-30 years	266.501
30-35 years	269.355
35-40 years	272.24
40-45 years	275.156
45-50 years	278.103
50-55 years	281.081
55-60 years	284.091
60-70 years	287.134
70-80 years	290.209
80-90 years	293.317
90-100 years	296.458
>100 years	299.633

High Prothrombin time and low TIBC can be caused by a lot of reasons. If you take Prothrombin time and TIBC blood tests and the results are higher than 16 seconds for Prothrombin time and lower than 250 mcg/dL for TIBC, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the Prothrombin time and TIBC Tests Are Done :

If your doctor wants Prothrombin time and TIBC tests on you, you may need to go through these tests. During the Prothrombin time and TIBC blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Prothrombin time and TIBC Test reports by your pathologist.

Medical References

• MedlinePlus – Prothrombin Time Test and INR (PT/INR)
• Mayo Clinic – Prothrombin time test
• Cleveland Clinic – Prothrombin Time (PT/INR) Test