What causes high Thrombin Time and low APTT?

High Thrombin Time and low APTT can be caused by many reasons.

If your Thrombin Time is in between 14 sec and 23 sec and your APTT is in between 22 seconds and 35 seconds then you need not worry as these are the normal ranges for Thrombin Time and APTT respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease Thrombin Time levels include:

• Anticoagulation drug (warfarin) therapy
• Vitamin K abnormality
• Decreased or defective factor I (fibrinogen), II (prothrombin), V or X
• Hemophilia A and hemophilia B
• Autoantibody against a specific factor (e.g., factor VIII)

Normal range of Thrombin Time : 14 - 23 sec

Ideal values of Thrombin Time depending on age :

Age	Ideal Thrombin Time value
<5 years	1.011
5-10 years	1.022
10-15 years	1.033
15-20 years	1.044
20-25 years	1.055
25-30 years	1.066
30-35 years	1.077
35-40 years	1.088
40-45 years	1.1
45-50 years	1.112
50-55 years	1.124
55-60 years	1.136
60-70 years	1.148
70-80 years	1.16
80-90 years	1.172
90-100 years	1.184
>100 years	1.197

*Ideal values are calculated based on our database of patient records

Normal range of APTT : 22 - 35 seconds

Ideal values of APTT depending on age :

Age	Ideal APTT value
<5 years	22.233
5-10 years	22.469
10-15 years	22.707
15-20 years	22.948
20-25 years	23.191
25-30 years	23.437
30-35 years	23.685
35-40 years	23.936
40-45 years	24.19
45-50 years	24.446
50-55 years	24.705
55-60 years	24.967
60-70 years	25.232
70-80 years	25.499
80-90 years	25.769
90-100 years	26.042
>100 years	26.318

High Thrombin Time and low APTT can be caused by a lot of reasons. If you take Thrombin Time and APTT blood tests and the results are higher than 23 sec for Thrombin Time and lower than 22 seconds for APTT, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the Thrombin Time and APTT Tests Are Done :

If your doctor wants Thrombin Time and APTT tests on you, you may need to go through these tests. During the Thrombin Time and APTT blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Thrombin Time and APTT Test reports by your pathologist.

Medical References

• PubMed – Thrombin clotting time
• NIH – Coagulation Tests
• PubMed – The thrombin clotting time. Evaluation of Thromboquik