What causes high TIBC and low Vitamin B12?

High TIBC and low Vitamin B12 can be caused by many reasons.

If your TIBC is in between 250 mcg/dL and 450 mcg/dL and your Vitamin B12 is in between 211 pg/mL and 911 pg/mL then you need not worry as these are the normal ranges for TIBC and Vitamin B12 respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Some examples of conditions that can increase or decrease TIBC levels include:

• Iron deficiency
• Iron poisoning
• Inflammation
• Chronic liver disease
• Hemochromatosis

TIBC treatment - Click to read 10 GOLDEN ARTICLES on Anemia

Normal range of TIBC : 250 - 450 mcg/dL

Ideal values of TIBC depending on age :

Age	Ideal TIBC value
<5 years	254.385
5-10 years	258.847
10-15 years	263.387
15-20 years	268.007
20-25 years	272.708
25-30 years	277.491
30-35 years	282.358
35-40 years	287.311
40-45 years	292.35
45-50 years	297.478
50-55 years	302.696
55-60 years	308.005
60-70 years	313.407
70-80 years	318.904
80-90 years	324.498
90-100 years	330.19
>100 years	335.982

*Ideal values are calculated based on our database of patient records

Normal range of Vitamin B12 : 211 - 911 pg/mL

Ideal values of Vitamin B12 depending on age :

Age	Ideal Vitamin B12 value
<5 years	214.701
5-10 years	218.467
10-15 years	222.299
15-20 years	226.198
20-25 years	230.166
25-30 years	234.203
30-35 years	238.311
35-40 years	242.491
40-45 years	246.744
45-50 years	251.072
50-55 years	255.476
55-60 years	259.957
60-70 years	264.517
70-80 years	269.157
80-90 years	273.878
90-100 years	278.682
>100 years	283.57

High TIBC and low Vitamin B12 can be caused by a lot of reasons. If you take TIBC and Vitamin B12 blood tests and the results are higher than 450 mcg/dL for TIBC and lower than 211 pg/mL for Vitamin B12, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

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How the TIBC and Vitamin B12 Tests Are Done :

If your doctor wants TIBC and Vitamin B12 tests on you, you may need to go through these tests. During the TIBC and Vitamin B12 blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your TIBC and Vitamin B12 Test reports by your pathologist.

Medical References

• Cleveland Clinic – TIBC (Total Iron-Binding Capacity) Test
• WebMD – What to Know About Total Iron-Binding Capacity (TIBC) Test
• MedlinePlus – Total iron binding capacity